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Synfacts 2010(5): 0587-0587
DOI: 10.1055/s-0029-1219662
DOI: 10.1055/s-0029-1219662
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Iridium-Catalyzed ortho-Borylation of Benzoate Esters with Bis(pinacolato)diboron
T. Ishiyama*, H. Isou, T. Kikuchi, N. Miyaura*
Hokkaido University, Sapporo, Japan
Further Information
Publication History
Publication Date:
22 April 2010 (online)
Significance
Directed ortho-C-H borylation of benzoate esters with B2(pin)2 catalyzed by iridium complexes consistent of commercially available [Ir(cod)(OMe)]2 and P[3,5-(F3C)2C6H3]3 gives the corresponding aromatic boronic esters in high yield and excellent regioselectivity, opening a route to a variety of ortho-substituted benzoylated derivatives.