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Synfacts 2010(7): 0813-0813
DOI: 10.1055/s-0029-1220045
DOI: 10.1055/s-0029-1220045
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Addition of Grignard Reagents to N-Sulfonyl Azoalkenes
J. M. Hatcher, D. M. Coltart*
Duke University, Durham, USA
Further Information
Publication History
Publication Date:
22 June 2010 (online)
Significance
The copper(I)-catalyzed addition of organomagnesium reagents to in situ derived N-sulfonyl azoalkenes was shown to result in an umpolung alkylation enabling the synthesis of extremely sterically hindered compounds that cannot be accessed via the traditional enolate chemistry.