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Synlett 1997; 1997(8): 939-940
DOI: 10.1055/s-1997-952
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Synthesis of an N-Alkyl Derivative of 2'-Deoxyisoguanosine

Janos T. Kodra1 , Steven A. Benner2
  • 1Department of Chemistry, Swiss Federal Institute of Technology, Universitätsstrasse 16, CH 8092 Zürich, Switzerland
  • 2Department of Chemistry, University of Florida, Gainesville, Florida 32611, USA, Tel (352) 392 7773; Fax (352) 846 2580
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Publication History

Publication Date:
31 December 2000 (online)

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3',5'-O-bis-tert-butyldimethylsilyl-2'-deoxyguanosine is converted in two steps to 3',5'-O-tert-butyldimethylsilyl-6-O-aryl-2'-deoxyxanthosine. This compound is used to make a 2'-deoxyisoguanosine analog with a functionalized side chain.

non-standard nucleobase - ribozyme - isoguanosine