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Synlett 2005(6): 0939-0942
DOI: 10.1055/s-2005-864815
DOI: 10.1055/s-2005-864815
LETTER
© Georg Thieme Verlag Stuttgart · New York
Stereoselective Synthesis of Trisubstituted Tetrahydropyrans from Baylis-Hillman Derivatives via n-Bu3SnH-Mediated 6-Endo/6-Exo-trig Vinyl Radical Cyclization
Further Information
Received
22 December 2004
Publication Date:
23 March 2005 (online)
Publication History
Publication Date:
23 March 2005 (online)
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Abstract
The stereoselective 6-endo- and 6-exo-trig cyclization of propargyl and phenyl homopropargyl derivatives of Baylis-Hillman adducts by the use of n-Bu3SnH-mediated vinyl radical cyclization afforded poly-substituted functionalized tetrahydropyrans in good yield.
Key words
6-exo-trig - 6-endo-trig - vinyl radical cyclization - Baylis-Hillman adduct - tetrahydropyran - tri-n-butyl tinhydride
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