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Synfacts 2006(3): 0288-0288  
DOI: 10.1055/s-2006-931978
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 3,5-Disubstituted 1,2,4-Triazoles on PEG6000

Contributor(s): Yasuhiro Uozumi, Toshimasa Suzuka
X.-C. Wang*, J.-K. Wang, Y.-X. Da, Z.-J. Quan, Y.-X. Zong
Northwest Normal University, Lanzhou and Hexi University, Zhangye, P. R. of China
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Publication History

Publication Date:
21 February 2006 (online)

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Significance

3,5-Disubstituted 1,2,4-triazoles 4 were prepared via several steps starting from amines 1 anchored on the 3-methoxy-4-formyl­phenyl poly(ethylene glycol) (soluble polymer). Thus, the reaction of 1 with several aroylchlorides followed by treatment with Lawesson’s reagent gave the corresponding products 2. Further reaction with aryloxyacetic hydrazides in the presence of Hg(OAc)2 gave the desired triazoles 3, bound to a soluble polymer, with high purity. 3,5-Disubstituted 1,2,4-triazoles 4a-c were readily isolated via TFA-mediated cleavage from the corresponding PEG-supported triazoles 3 in high yields with high purity.