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Synfacts 2006(7): 0720-0720
DOI: 10.1055/s-2006-941881
DOI: 10.1055/s-2006-941881
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Highly Efficient Magnesiation of Functionalized Arenes and Heteroarenes
A. Krasovskiy, V. Krasovskaya, P. Knochel*
Ludwig-Maximilians-Universität München, Germany
Further Information
Publication History
Publication Date:
22 June 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200607/lookinside/thumbnails/10.1055-s-2006-941881-1.jpg)
Significance
The direct selective metallation of arenes and hetarenes is an extremely synthetically attractive process, which allows an easy polyfunctionalization of these compounds. Such metallation usually requires cryogenic temperatures and/or large excess of a base. This new method has many excellent advantages: only a slight excess of the metallating reagent is required, the reactions are almost always chemoselective and proceed at temperatures usually not below -30 °C. The reactions of the resulting organometallic species with electrophiles uniformly give excellent yields of products.