Mechanistic Studies on the Roles of Cosolvents and Additives in Samarium(II)-Based Reductions

Robert A. Flowers II

doi:10.1055/s-2008-1078414

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Synlett 2008(10): 1427-1439
DOI: 10.1055/s-2008-1078414

ACCOUNT

Mechanistic Studies on the Roles of Cosolvents and Additives in Samarium(II)-Based Reductions

Robert A. Flowers, II*
Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, USA
Fax: +1(610)7586536; e-Mail: rof2@lehigh.edu;

Further Information

Publication History

Received 19 January 2008
Publication Date:
16 May 2008 (online)

Abstract
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Abstract

This account describes work, performed by my research group during the past decade, designed to understand the mechanistic roles of cosolvents and additives in reductions involving samarium(II) iodide (SmI₂). Emphasis is placed on studies designed to elucidate the roles of the cosolvent hexamethylphosphoramide (HMPA) and proton donors (water, alcohols, and glycols) in the mechanisms of important bond-forming reactions and reductions initiated by SmI₂.

1 Background and Introduction

1.1 Project Inception

2 Mechanistic Studies on the Role of Hexamethylphosphoramide in the Reactions of Samarium(II) Iodide

3 Impact of Proton Donors on the Mechanism of Substrate Reduction

4 Conclusions and Future Work

Key words

samarium(II) iodide - electron transfer - hexamethylphosphoramide - proton donors - reductions

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Shotwell, J. B. unpublished results.