Coupling of Cyclopropyl- and Cyclobutyl-trifluoroborates
with Aryl Chlorides

doi:10.1055/s-0028-1083587

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook Linkedin Weibo

Download PDF

Synfacts 2008(12): 1318-1318
DOI: 10.1055/s-0028-1083587

Metal-Mediated Synthesis

Coupling of Cyclopropyl- and Cyclobutyl-trifluoroborates with Aryl Chlorides

Contributor(s): Paul Knochel, Andrei Gavryushin
G. A. Molander*, P. E. Gormisky
University of Pennsylvania, Philadelphia, USA

Further Information

Publication History

Publication Date:
20 November 2008 (online)

Permissions and Reprints

Significance

Specific steric and electronic properties of cyclopropyl and cyclobutyl groups give interesting opportunities for the creation of new biologically active molecules. This convenient and versatile method protocol uses cycloalkyltrifluoroborates as shelf-stable cycloalkyl nucleophiles, and inexpensive aryl chlorides as coupling partners.