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Synfacts 2008(12): 1308-1308
DOI: 10.1055/s-0028-1087317
DOI: 10.1055/s-0028-1087317
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Rhodium-Catalyzed Asymmetric Hydrogenation of Cyclic Imines
C. Li, J. Xiao*
University of Liverpool, UK
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. November 2008 (online)

Significance
An efficient cationic Rh(III)-diamine-catalyzed asymmetric hydrogenation of cyclic imines is presented. Good to excellent yields and enantioselectivities of the resulting tetrahydroisoquinolines and tetrahydro-β-carbolines are observed. In general, bulkier substituents on the imine require longer reaction times and show decreased enantioselectivities.