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Synfacts 2008(12): 1308-1308  
DOI: 10.1055/s-0028-1087317
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rhodium-Catalyzed Asymmetric Hydrogenation of Cyclic Imines

Contributor(s): Mark Lautens, Praew Thansandote
C. Li, J. Xiao*
University of Liverpool, UK
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

An efficient cationic Rh(III)-diamine-catalyzed asymmetric hydrogenation of cyclic imines is presented. Good to excellent yields and enantioselectivities of the resulting tetrahydro­isoquinolines and tetrahydro-β-carbolines are observed. In general, bulkier substituents on the imine require longer reaction times and show decreased enantioselectivities.