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Synfacts 2009(2): 0170-0170  
DOI: 10.1055/s-0028-1087509
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

A New Phosphine-Aminophosphine Ligand for Enantioselective Hydrogenation

Contributor(s): Hisashi Yamamoto, Cheol Hong Cheon
M. Qiu, X.-P. Hu*, J.-D. Huang, D.-Y. Wang, J. Deng, S.-B. Yu, Z.-C. Duan, Z. Zheng*
Dalian Institute of Chemical Physics and The Graduate School of Chinese Academy of Sciences, Beijing, P. R. of China
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Publikationsdatum:
22. Januar 2009 (online)

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Significance

In this paper, the authors have developed a new class of readily available, air-stable chiral phosphine-aminophosphine (PAP) ligands and their successful application to the enantio­selective hydrogenation of various functionalized olefins. Excellent enantioselectivities have been achieved for most substrates examined, which demonstrated the high potential of these ligands in preparation of biologically interesting compounds.