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Synfacts 2009(8): 0895-0895  
DOI: 10.1055/s-0029-1217476
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Ti(III)-Promoted Couplings of Epoxides with Nitriles

Contributor(s): Paul Knochel, Andreas J. Wagner
A. Fernández-Mateos*, S. Encinas Madrazo, P. Herrero Teijón, R. Rubio González
Universidad de Salamanca, Spain
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Publikationsverlauf

Publikationsdatum:
23. Juli 2009 (online)

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Significance

The radical couplings of epoxides and nitriles mediated by titanocene chloride provide a diastereoselective route to the synthesis of β-hydroxy ketones. A moderate anti-selectivity is observed and the hydroxy ketones are usually isolated in good yields.