Download PDF
Synfacts 2009(8): 0895-0895  
DOI: 10.1055/s-0029-1217476
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Ti(III)-Promoted Couplings of Epoxides with Nitriles

Contributor(s): Paul Knochel, Andreas J. Wagner
A. Fernández-Mateos*, S. Encinas Madrazo, P. Herrero Teijón, R. Rubio González
Universidad de Salamanca, Spain
Further Information

Publication History

Publication Date:
23 July 2009 (online)

    Permissions and Reprints

Significance

The radical couplings of epoxides and nitriles mediated by titanocene chloride provide a diastereoselective route to the synthesis of β-hydroxy ketones. A moderate anti-selectivity is observed and the hydroxy ketones are usually isolated in good yields.