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Synfacts 2009(8): 0935-0935  
DOI: 10.1055/s-0029-1217494
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

A Phosphine Ligand Bearing EG12 for the Suzuki-Miyaura Coupling

Contributor(s): Yasuhiro Uozumi, Yoshikazu Yamamoto
T. Fujihara, S. Yoshida, J. Terao, Y. Tsuji*
Kyoto University, Japan
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Publikationsverlauf

Publikationsdatum:
23. Juli 2009 (online)

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Significance

A triarylphosphine ligand bearing dodeca(ethylene glycol) chains (EG12-Phos) was prepared in six steps (eq. 1). EG12-Phos enhanced the activity of palladium to promote the Suzuki-Miyaura coupling of unactivated aryl chlorides with arylboronic acids affording the coupling products in up to 99% yield (10 examples).