Synfacts 2009(12): 1395-1395  
DOI: 10.1055/s-0029-1218166
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Iron-Catalyzed Cross-Coupling of Alkyl Sulfonates with Arylzinc Reagents

Contributor(s): Paul Knochel, Andrei Gavryushin
S. Ito, Y.-i. Fujiwara, E. Nakamura, M. Nakamura*
Kyoto University, Japan
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Publikationsverlauf

Publikationsdatum:
20. November 2009 (online)

Significance

An efficient cross-coupling of various primary and secondary alkyl tosylates and mesylates with arylzinc species can be achieved using cheap and environmentally benign iron catalysis under mild conditions. This reaction tolerates many functional groups, usually compatible with organozinc chemistry, like an ester or a nitrile.