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Synfacts 2009(12): 1308-1308  
DOI: 10.1055/s-0029-1218330
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Formal Synthesis of Platensimycin

Contributor(s): Philip Kocienski, Zofia Komsta
S. Y. Yun, J.-C. Zheng, D. Lee*
University of Illinois at Chicago, USA
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Publikationsdatum:
20. November 2009 (online)

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Significance

Platensimycin, isolated from a strain of Streptomyces platensis, is a potent antibacterial agent. Its novel mechanism of action (inhibition of bacterial fatty acid biosynthesis) promises a remedy for multidrug-resistant bacterial infections. For the total synthesis of platensimycin see: K. C. Nicolaou, A. Li, D. J. Edmonds Angew. Chem. Int. Ed. 2006, 45, 7086.