Coupling Isocyanide-Based
Multicomponent Reactions with Aliphatic or Acyl Nucleophilic Substitution
Processes
Luca Banfi*, Renata Riva*, Andrea Basso Department of Chemistry and Industrial
Chemistry, University of Genova, via
Dodecaneso 31, 16146 Genova, Italy Fax: +39(010)3536118; e-Mail: banfi@chimica.unige.it; e-Mail: riva@chimica.unige.it;
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Publikationsverlauf
Received
17 July 2009 Publikationsdatum: 30. November 2009 (online)
This account summarizes the results of studies carried out by
the authors during the last 10 years aimed at expanding the utility
of the venerable Passerini and Ugi reactions. Particular emphasis
is given to efforts that focus on coupling these processes with post-condensation,
intramolecular, aliphatic nucleophilic substitution and acyl nucleophilic
substitution reactions. The methodologies developed in these investigations
serve as the basis for short sequences for the preparation of a
diverse number of interesting drug-like structures.
1 Introduction
2 Aliphatic Nucleophilic Substitution
2.1 Two Additional Functions: Mitsunobu or Mitsunobu-like Reactions
2.2 One Additional Function: Ketopiperazines, β-Lactams
and More
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Banfi, L.; Basso, A.; Cerulli, V.;
Guanti, G.; Lecinska, P.; Riva, R. IV Int.
Conference on ‘Multi-Component Reactions and Related Chemistry’,
Ekaterinburg: Russia, 24-28/5, 2009,
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Banfi, L.; Basso, A.; De Moliner,
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Int. Conference on ‘Multi-Component Reactions and Related
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