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Synfacts 2010(8): 0856-0856
DOI: 10.1055/s-0030-1257742
DOI: 10.1055/s-0030-1257742
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of MK-5596
L. Yan et al.*
Merck Research Laboratories, Rahway, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juli 2010 (online)
Significance
The cannabinoid-1 receptor (CB1R) is a G-protein coupled receptor, widely expressed in the CNS and peripheral tissues, that plays an important role in regulating energy balance. MK-5596 is a CB1R inverse agonist that reduces body weight and food intake in obese rats and hence is being developed for the treatment of obesity.