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Synfacts 2010(8): 0860-0860  
DOI: 10.1055/s-0030-1257769
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Cubebol

Contributor(s): Steven V. Ley, Kimberley A. Roper
D. M. Hodgson*, S. Salik, D. J. Fox
University of Oxford and University of Warwick, Coventry, UK
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

(-)-Cubebol, a major constituent of cubeb oil, has long-found medicinal and culinary uses. Recently, it has been patented as a sustained cooling and refreshing agent in the area of flavors. Two previous syntheses from (R)-carvone have been published utilizing metal-catalyzed ­cycloisomerizations from the corresponding propargylic esters.