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Synlett 2010(18): 2781-2783  
DOI: 10.1055/s-0030-1258819
LETTER
© Georg Thieme Verlag Stuttgart ˙ New York

Condensed Oxaziridine-Mediated [3+2] Cycloaddition: Synthesis of Polyhetero-bicyclo Compounds

Valeria Videtta, Serena Perrone, Francesca Rosato, Pietro Alifano, Salvatore M. Tredici, Luigino Troisi*
Dipartimento di Scienze e Tecnologie Biologiche ed Ambientali, University of Salento, via Prov.le Lecce-Monteroni, 73100 Lecce, Italy
Fax: +39(0832)298732; e-Mail: luigino.troisi@unisalento.it;
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Publication History

Received 19 July 2010
Publication Date:
08 October 2010 (online)

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Abstract

Polyhetero-bicyclo compounds were synthesized by a regioselective [3+2]-cycloaddition reaction between stable condensed oxaziridines and alkenes, alkynes, and nitriles. These molecules showed considerable antimicrobial activity against several gram-positive bacteria.

Key words

condensed oxaziridines - polyhetero-bicyclo - regio­selectivity - [3+2] cycloaddition - bactericidal properties