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Synfacts 2011(1): 0012-0012  
DOI: 10.1055/s-0030-1258974
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ACT-178882 (MK-1597)

Contributor(s): Philip Kocienski
O. Bezençon et al.*
Actelion Pharmaceuticals, Allschwill, Switzerland
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Publikationsdatum:
21. Dezember 2010 (online)

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Significance

The rennin-angiotensin-aldosterone system (RAAS) regulates arterial blood pressure in humans, and plays a crucial role in cardiovascular, renal, and other metabolic diseases. ACT-178882 (MK-1597) is a renin inhibitor with a suitable profile for development.