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Synfacts 2011(1): 0088-0088
DOI: 10.1055/s-0030-1259120
DOI: 10.1055/s-0030-1259120
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Regio- and Stereoselective Silyl Enol Ethers
A. Tsubouchi, S. Enatsu, R. Kanno, T. Takeda*
Tokyo University of Agriculture and Technology, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Dezember 2010 (online)
Significance
This work discloses a three-component coupling for the preparation of trisubstituted silyl enol ethers from α-silyl α,β-unsaturated ketones, organocopper reagents, and organic halides. The reaction proceeds with complete regio- and stereoselectivity and is found to be general for α-silylvinyl ketones as well as aliphatic primary and secondary ketones.