Download PDF
Synfacts 2011(1): 0088-0088  
DOI: 10.1055/s-0030-1259120
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Regio- and Stereoselective Silyl Enol Ethers

Contributor(s): Paul Knochel, Thomas Kunz
A. Tsubouchi, S. Enatsu, R. Kanno, T. Takeda*
Tokyo University of Agriculture and Technology, Japan
Further Information

Publication History

Publication Date:
21 December 2010 (online)

    Permissions and Reprints

Significance

This work discloses a three-component coupling for the preparation of trisubstituted silyl enol ethers from α-silyl α,β-unsaturated ­ketones, organocopper reagents, and organic ­halides. The reaction proceeds with complete ­regio- and stereoselectivity and is found to be general for α-silylvinyl ketones as well as aliphatic primary and secondary ketones.