C-H Alkylation of Heteroarenes with Alkyl- and Alkoxymethyltrifluoroborates

G. A. Molander; V. Colombel; V. A. Braz

doi:10.1055/s-0030-1260365

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2011(6): 0657-0657
DOI: 10.1055/s-0030-1260365

Metal-Mediated Synthesis

C-H Alkylation of Heteroarenes with Alkyl- and Alkoxymethyltrifluoroborates

Contributor(s): Paul Knochel, Andreas K. Steib
G. A. Molander*, V. Colombel, V. A. Braz
University of Pennsylvania, Philadelphia, USA

Further Information

Publication History

Publication Date:
19 May 2011 (online)

Buy Article Permissions and Reprints

Significance

A new direct C-H alkylation of various heterocycles using potassium alkyl- and alkoxymethyltrifluoroborates is described. The highest yields were obtained with Mn(OAc)₃ as oxidant in the presence of trifluoroacetic acid in a 1:1 mixture of acetic acid and water.