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Synfacts 2011(8): 0880-0880  
DOI: 10.1055/s-0030-1260745
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Silver-Catalyzed Asymmetric [3+2] Cycloaddition of Amino Esters to Olefins

Contributor(s): Hisashi Yamamoto, Jiajing Tan
Y. Yamashita, T. Imaizumi, S. Kobayashi*
The University of Tokyo, Japan
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Publication History

Publication Date:
20 July 2011 (online)

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Significance

This report describes a highly enantioselective and exo-selective [3+2] cyclo­addition of α-amino ester Schiff bases with various activated olefins. The corresponding highly substituted pyrrolidine derivatives, which are important building blocks for biologically active molecules, are obtained efficiently.