(4-Hydroxy-TEMPO)-Catalyzed Synthesis of 2-Aryl Quinazolines

Significance

Reported is a metal-free catalytic synthesis of 2-aryl quinazolines by the reaction of arylmethanamines with 2-aminobenzoketones or 2-aminobenzaldehydes. This aerobic oxidative synthesis proceeds smoothly under 4-hydroxy-TEMPO catalysis conditions via imine formation followed by intramolecular benzyl C-H amination to afford the 2-aryl quinazoline products in moderate to good yields. The reaction scope and limitations were investigated broadly for both starting materials.