A Concise Synthesis of 4-Vinylphencyphos

Abstract

A fast and clean procedure has been found to prepare the 4-vinyl derivative of enantiomerically pure 2-hydroxy-5,5-dimethyl-4-phenyl-1,3,2-dioxaphosphinan-2-oxide, commonly known as phencyphos. This cyclic phosphoric acid is a popular acidic resolving agent. Functionalization opens a route to attachment to surfaces.

Key words

Hiyama coupling - resolving agent - phosphoric acid - chiral

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