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Synfacts 2006(2): 0104-0104  
DOI: 10.1055/s-2005-924812
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (S)-1-Amino-5-phosphonoindan-1-carboxylic Acid [(S)-APICA]

Contributor(s): Philip Kocienski
J. T. Suri, D. D. Steiner, III C. F. Barbas *
The Scripps Research Institute, La Jolla, USA
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Publikationsdatum:
23. Januar 2006 (online)

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Significance

(S)-1-Amino-5-phosphonoindan-1-carboxylic acid [(S)-APICA] antagonises metabotropic glutamate receptors implicated in various neurodegenerative diseases. The α-amination of aldehyde B in the short synthesis of (S)-APICA outlined above is another triumph for proline organocatalysis.