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Synfacts 2006(2): 0104-0104
DOI: 10.1055/s-2005-924812
DOI: 10.1055/s-2005-924812
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (S)-1-Amino-5-phosphonoindan-1-carboxylic Acid [(S)-APICA]
J. T. Suri, D. D. Steiner, III C. F. Barbas *
The Scripps Research Institute, La Jolla, USA
Further Information
Publication History
Publication Date:
23 January 2006 (online)
Significance
(S)-1-Amino-5-phosphonoindan-1-carboxylic acid [(S)-APICA] antagonises metabotropic glutamate receptors implicated in various neurodegenerative diseases. The α-amination of aldehyde B in the short synthesis of (S)-APICA outlined above is another triumph for proline organocatalysis.