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Thromb Haemost 2015; 114(02): 228-236
DOI: 10.1160/TH14-11-0962
Review Article
Schattauer GmbH

Microvesicles from platelets: novel drivers of vascular inflammation

Tanja Vajen
1   Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands
,
Sebastian F. Mause
2   Department of Cardiology, Medical Clinic I, Medical Faculty, University Hospital RWTH Aachen, Aachen, Germany
,
Rory R. Koenen
1   Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands
› Author Affiliations
Further Information

Publication History

Received: 19 November 2014

Accepted after major revision: 03 March 2015

Publication Date:
01 December 2017 (online)

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Summary

Microvesicles are receiving increased attention not only as biomarkers but also as mediators of cell communication and as integral effectors of disease. Platelets present a major source of microvesicles and release these microvesicles either spontaneously or upon activation. Platelet-derived microvesicles retain many features of their parent cells and have been shown to exert modulatory effects on vascular and immune cells. Accordingly, microvesicles from platelets can be measured at increased levels in patients with cardiovascular disease or individuals at risk. In addition, isolated microvesicles from platelets were shown to exert immunomodulatory actions on various cell types. In this review the various aspects of platelet-derived microvesicles including release, clearance, measurement, occurrence during disease and relevance for the pathophysiology of vascular inflammation will be discussed.

Keywords

Platelet - microvesicle - microparticle - vascular inflammation - atherosclerosis
 

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