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Synfacts 2008(12): 1295-1295  
DOI: 10.1055/s-0028-1083619
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Hydroarylation of Alkenes via C-H Activation

Contributor(s): Hisashi Yamamoto, Marina Naodovic
H. Harada, R. K. Thalji, R. G. Bergman*, J. A. Ellman*
University of California, Berkeley, USA
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

Described in this report is one the rare examples of enantioselective aromatic C-H bond activation reaction. Rh-phosphoramidite catalyst systems efficiently catalyze the intramolecular hydroarylation of alkenes to provide syn-products with high enantioselectivities and good yields. The main significance of this methodology is a broad substrate scope.