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Synfacts 2008(12): 1296-1296  
DOI: 10.1055/s-0028-1087319
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium-Catalyzed Asymmetric α-Arylation of Aldehydes

Contributor(s): Mark Lautens, Jane Panteleev
J. García-Fortanet, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
20 November 2008 (online)

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Significance

The authors report the first asymmetric version of the α-arylation of aldehydes under palladium catalysis. The examples illustrated are all intramolecular, generating five- and six-membered rings. The method forms all-carbon- substituted quaternary centers in high enantioselectivity and moderate yield.