Download PDF
Synfacts 2009(8): 0872-0872  
DOI: 10.1055/s-0029-1217416
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Palladium/Quinox-Catalyzed Wacker-Type Oxidation of Terminal Olefins

Contributor(s): Hisashi Yamamoto, Pingfan Li
B. W. Michel, A. M. Camelio, C. N. Cornell, M. S. Sigman*
University of Utah, Salt Lake City, USA
Further Information

Publication History

Publication Date:
23 July 2009 (online)

    Permissions and Reprints

Significance

Protected allylic alcohols among other terminal olefins undergo a successful ­Wacker-type oxidation using TBHP as an oxidant under palladium-catalyzed conditions. The idea of introducing a bidentate ligand to alleviate anti-Markovnikov products is discussed. It is found that the use of quinoline-2-oxazoline (Quinox) ligand is very crucial.