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Synfacts 2009(8): 0902-0902  
DOI: 10.1055/s-0029-1217479
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

CuBr-Catalyzed Oxidative Difluoromethylation of Tertiary Amines

Contributor(s): Paul Knochel, Andreas J. Wagner
L. Chu, X. Zhang, F.-L. Qing*
Institute of Organic Chemistry and Donghua University, Shanghai, P. R. of China
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Publication History

Publication Date:
23 July 2009 (online)

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Significance

In the presence of catalytic amounts of CuBr, various readily available tertiary amines react with difluoroenol silyl ethers, undergoing an oxidative difluoromethylation reaction that proceeds under mild conditions affording β-amino-α,α-difluoro ketones in up to 88% yield.