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Synfacts 2009(8): 0932-0932
DOI: 10.1055/s-0029-1217503
DOI: 10.1055/s-0029-1217503
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Gold Supported on Hydroxyapatite as a Tandem Catalyst
H. Sun*, F.-Z. Su, J. Ni, Y. Cao, H.-Y. He*, K.-N. Fan*
Fudan University, Shanghai, P. R. of China
Further Information
Publication History
Publication Date:
23 July 2009 (online)
Significance
A direct tandem synthesis of imines and oximes from alcohols by using gold nanoparticles supported on hydroxyapatite [HAP: Ca10(PO4)6(OH)2] was described. Reaction of alcohols with amines with Au/HAP (Au: 1 mol%, 130 mg) under oxygen afforded the corresponding imines (15 examples, 75-99% conversion, 90-99% selectivity, 1-16 h) by a facile tandem oxidation-condensation pathway. The Au/HAP catalyst system was also applied to the tandem synthesis of oximes from alcohols and hydroxylamine (5 examples, 92-97% yield, 2.5-6.5 h).