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Synfacts 2009(11): 1228-1228  
DOI: 10.1055/s-0029-1218078
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Rh-Catalyzed Hydrogena-tion of 3-Aryl-2-phosphonomethylpropenoates

Contributor(s): Hisashi Yamamoto, Pingfan Li
D.-Y. Wang, X.-P. Hu*, C.-J. Hou, J. Deng, S.-N. Yu, Z.-C. Duan, J.-D. Huang, Z. Zheng*
Dalian Institute of Chemical Physics and Graduate School of the Chinese Academy of Sciences, Beijing, P. R. of China
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Publikationsdatum:
22. Oktober 2009 (online)

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Significance

Enantioselective hydrogenation of 2-phosphonomethylpropenoate derivatives provides direct access to the useful chiral 3-phos-phono-2-alkylpropanoic acid derivatives. This communication documents the development of a new class of chiral ferrocenyl diphosphine ligands, which contain an imidazole ring. The ligand synthesis is straightforward and the enantioselectivity of the rhodium-catalyzed reaction is very good.