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Synfacts 2009(11): 1215-1215  
DOI: 10.1055/s-0029-1218099
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Isobenzofurans and Cyclophanes

Contributor(s): Timothy M. Swager, Trisha L. Andrew
S. J. Robbins, M. E. Thibault, J. D. Masuda, D. R. Ward, R. T. Boeré, P. W. Dibble*
University of Lethbridge, Canada
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Publication History

Publication Date:
22 October 2009 (online)

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Significance

Naphthofuran 1 was synthesized in moderate yields from a bis(acetal). 1 was found to be stable and could be stored for several months under cool and dark conditions. A subsequent two-fold Diels-Alder reaction with the tethered bis(maleimide) 2 yielded the stable cyclophane 3.