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Synfacts 2009(12): 1411-1411  
DOI: 10.1055/s-0029-1218198
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Knoevenagel Reaction Catalyzed by Dendrimeric Nano-Silica PAMAM

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Elisabetta Greco
H. Hagiwara*, M. Sekifuji, N. Tsubokawa, T. Hoshi, T. Suzuki
Niigata University, Japan
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Publication History

Publication Date:
20 November 2009 (online)

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Significance

A Knoevenagel reaction catalyzed by silica-supported amino dendrimers was described. The third generation amino dendrimers (nano-PAMAM and nano-PAMDMAM) were prepared by spraying methyl acrylate and ethylene­diamine alternately onto nano-NAP. The optimal Knoevenagel reaction conditions were identified (see table entries 4 and 6, respectively).