Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2009(12): 1369-1369
DOI: 10.1055/s-0029-1218247
DOI: 10.1055/s-0029-1218247
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Heteroaryl Titanates and Zinc Reagents in Enantioselective Conjugate Addition
A. J. Smith, L. K. Abbott, S. F. Martin*
The University of Texas at Austin, USA
Further Information
Publication History
Publication Date:
20 November 2009 (online)
Significance
The development of the enantioselective conjugate addition of aryl nucleophiles to Michael acceptors is an important objective in modern organic synthesis. The addition of 2-heteroaryl nucleophiles remains an obstacle mainly due to the instability of 2-heteroarylboronic acids. The authors describe a general strategy for the conjugate addition of 2-heteroaryl titanates and zinc reagents to cyclic enones, unsaturated lactones, and unsaturated lactams in high enantioselectivities and yields.