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Synfacts 2010(3): 0270-0270  
DOI: 10.1055/s-0029-1219249
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Zoanthenol

Contributor(s): Steven V. Ley, Kimberley A. Roper
Y. Takahashi, F. Yoshimura, K. Tanino*, M. Miyashita*
Hokkaido University, Sapporo, Japan
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

The zoanthamine alkaloids, a family of marine metabolites, have a novel array of structures and show potential anti-osteoporotic properties. The synthesis of norzoanthamine and zoanthamine has been previously published by the same group and now a route to zoanthenol has been completed by using a tautomerization strategy from the manipulation of a previously prepared precursor for the other natural products.