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Synfacts 2010(8): 0925-0925  
DOI: 10.1055/s-0030-1257823
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Hydrogenation of α-Dehydroamino Acid Esters

Contributor(s): Hisashi Yamamoto, Jiajing Tan
X. Sun, W. Li, L. Zhou, X. Zhang*
The State University of New Jersey, Piscataway, USA and Northwest A&F University, Yangling, P. R. of China
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

In this work, the authors reported a concise preparation of modular and fine-tunable chiral bisaminophosphine ligands, which were successfully applied to the enantioselective hydrogenation of α-dehydroamino acid esters. Various amino acids have been obtained with excellent yields and enantioselectivities.