Synthesis of a Corticotropin-Releasing Factor Antagonist

A. Ribecai et al.

doi:10.1055/s-0030-1258071

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Synfacts 2010(10): 1093-1093
DOI: 10.1055/s-0030-1258071

Synthesis of Natural Products and Potential Drugs

Synthesis of a Corticotropin-Releasing Factor Antagonist

Contributor(s): Philip Kocienski
A. Ribecai et al.*
GlaxoSmithKline Medicines Research Centre, Verona, Italy

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Publication History

Publication Date:
22 September 2010 (online)

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Significance

Corticotropin-releasing factor (CRF-1) plays a central role in mediating behavioral, neuroendocrine, and autonomic responses to stress. Therefore, CRF-1 antagonists are a potential treatment for stress-related illness. The large-scale route depicted delivered 100 kg of the CRF-1 antagonist H in 30% overall yield.