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Synfacts 2010(10): 1097-1097  
DOI: 10.1055/s-0030-1258622
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (-)-Decarestrictine D

Contributor(s): Steven V. Ley, Catherine F. Carter
M. Binanzer, G. Y. Fang, V. K. Aggarwal*
University of Bristol, UK
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

(-)-Decarestrictine D is a ten-membered lactone isolated from both Penicillium corylophilum and Polyporous tuberaster. It displays ­inhibitory activity for liver cell cholesterol biosynthesis (IC50 = 100 nM).