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Synfacts 2010(10): 1167-1167  
DOI: 10.1055/s-0030-1258652
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Dehydrogenative Cross-Coupling

Contributor(s): Mark Lautens, David A. Candito
C. Guo, J. Song, S.-W. Luo, L.-Z. Gong*
University of Science and Technology of China, Hefei, P. R. of China
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

The ability to selectively functionalize C-H bonds in complex substrates continues to be of interest. The authors report on the copper-catalyzed asymmetric dehydrogenative cross-coupling of indolylmethyl C-H bonds with 1,3-dicarbonyl compounds. Indole derivatives feature prominently in natural products and drug targets making this strategy particularly useful.