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Synfacts 2010(10): 1203-1203
DOI: 10.1055/s-0030-1258659
DOI: 10.1055/s-0030-1258659
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
EVOH Capillary Supported Palladium Catalyst for Flow Transfer Hydrogenation
C. H. Hornung, B. Hallmark, M. R. Mackley*, I. R. Baxendale, S. V. Ley*
University of Cambridge, UK
Further Information
Publication History
Publication Date:
22 September 2010 (online)
Significance
Ethylene vinyl alcohol (EVOH) copolymer microcapillary flow discs (MFDs) containing nineteen capillaries were developed, where the wall surface of the microcapillaries was coated with palladium nanoparticles. Transfer hydrogenation of various unsaturated functional groups (e.g., C=C, C=O, C=N, etc.) was carried out using the palladium-coated multi-channel flow microreactor with Et3SiH at room temperature for 30 minutes (flow rate: 0.1 mL/min substrate) to give the corresponding products in 75-96% yield.