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Synfacts 2010(10): 1185-1185  
DOI: 10.1055/s-0030-1258674
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective α-Aminoxylation of Enecarbamates

Contributor(s): Benjamin List, Anna Lee
M. Lu, Y. Lu, D. Zhu, X. Zeng, X. Li, G. Zhong*
Nanyang Technological University, Singapore
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

An efficient chiral phosphoric acid catalyzed α-aminoxylation of enecarbamates is described. Zhong and co-workers proposed a ­selective O-addition pathway in the presence of an electron-withdrawing carbamate group and the desired products were obtained in high enantio­selectivities and good yields. The authors also showed the synthetic utility of this procedure; ­protected β-amino alcohols and cis-oxazolidinone were obtained successfully.