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Synfacts 2010(10): 1155-1155  
DOI: 10.1055/s-0030-1258688
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Asymmetric Hydrogenation of Trisubstituted Olefins

Contributor(s): Hisashi Yamamoto, Zhi Li
D. H. Woodmansee, M.-A. Müller, M. Neuburger, A. Pfaltz*
University of Basel, Switzerland
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

In order to perform highly efficient asymmetric hydrogenation on some difficult substrates, such as trisubstituted olefins, the authors designed and synthesized a series of chiral pyridyl phosphinite ligands that facilitate unprecedented iridium-catalyzed asymmetric hydrogenation of these substrates.