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Synfacts 2010(10): 1147-1147  
DOI: 10.1055/s-0030-1258692
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

New Quinaphos Ligands for Asymmetric Hydrogenation

Contributor(s): Hisashi Yamamoto, Jiajing Tan
T. Pullmann, B. Engendahl, Z. Zhang, M. Hölscher, A. Zanotti-Gerosa, A. Dyke, G. Franciò*, W. Leitner*
RWTH Aachen University, Germany; Johnson Matthey, Cambridge, UK
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

New members of the Quinaphos-type ligands have been synthesized by a simple protocol and fully characterized. These new Quinaphos ligands with a more flexible 1,2,3,4-tetrahydroquinoline backbone were shown to be extremely effective for asymmetric hydrogenation of functionalized olefins, dehydroamino acid derivatives as well as enamides.