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Synfacts 2006(11): 1088-1088  
DOI: 10.1055/s-2006-949383
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Yatakemycin

Contributor(s): Philip Kocienski, Thomas Snaddon
K. Okano, H. Tokuyama, T. Fukuyama*
The University of Tokyo, Japan
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Publication History

Publication Date:
24 October 2006 (online)

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Significance

Isolated from Streptomyces sp. TP-A0356, (+)-yatakemycin is a potent antitumor antibiotic, which acts by the sequence-selective alkylation of DNA. Key to this synthesis is the preparation of fragments E, L, and I in expedient and high-yielding fashion by copper-mediated aryl amination reactions.