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Synfacts 2006(11): 1092-1092  
DOI: 10.1055/s-2006-949397
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Abyssomicin C

Contributor(s): Philip Kocienski, Thomas Snaddon
K. C. Nicolaou*, S. T. Harrison
The Scripps Research Institute, La Jolla and University of California, San Diego, La Jolla, USA
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Publication History

Publication Date:
24 October 2006 (online)

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Significance

Abyssomicin C is a structurally interesting antibiotic that displays activity against methicillin- and vancomycin-resistant Staphylococcus aureus. Nicolaou and Harrison have developed a Lewis acid templated Diels-Alder reaction (C → F) en route to the oxabicyclo[2.2.2]octane core.